They play their home games at the Estadio Metropolitano Ciudad de Itagüí.

Thanks to its performances and achievements in the 80s the club was admitted in the first edition of the Categoría Primera B, the second-tier of the professional Colombian league, played in 1991.

In 2008 Deportivo Rionegro, with René Higuita as their captain and star and with Óscar Aristizábal as manager, managed to win the first tournament of the year, defeating Unión Magdalena in the final, but in the second half failed to reach the final, so they had to fight for the title of the Primera B against Real Cartagena, losing on aggregate by 2-4.

Leones ended as runners-up in the 2017 Primera B, winning the Torneo Finalización and then going on to lose the final to Boyacá Chicó on penalty kicks.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.