This proved too difficult a task, but Plyushch published papers on modeling and regulating simpler biological systems like the blood sugar level.

He was eventually hired by the Institute of Cybernetics of the USSR Academy of Sciences, which was often tasked with solving various problems for the Soviet space program.

[6] Due to blowback from his political stances, he was dismissed from the Cybernetics Institute in 1968, and the KGB confiscated a number of his manuscripts and interrogated him several times.

Although no expert witnesses of any kind were called, Plyushch was declared insane, and was ordered to be "sent for treatment in a special type of hospital."

He was locked up in a ward for severely psychotic patients in the Dnipropetrovsk Special Psychiatric Hospital where high doses of haloperidol, insulin and other drugs were administered, which temporarily made him incapable of reading and writing.

[9][10] Three commissions that examined him after a year of detention, one of which was chaired by Andrei Snezhnevsky, found him suffering from "reformist delusions" with "Messianic elements" and "sluggish schizophrenia.

"[11] On 28 November 1976, Plyushch said, Moscow has taken advantage of the Helsinki security pact to improve its economy while increasing the suppression of political dissenters.

[17][18] At a press conference in Paris, Plyushch gave a memorable account of the effects of his detention and medications:[19] I noted with horror the daily progression of my degradation.

[23] In 1980, Andrei Snezhnevsky, who was a Corresponding Fellow of the Royal College of Psychiatry, was invited by his British colleagues to answer criticism relating to Plyushch and other dissidents.

[25] In 2006, he translated the book Talking with angels (originally Dialogues avec l'ange, ISBN 978-2700700350) into Russian[26] and Ukrainian[27] with his wife Tatiana.