[4] These molecular machines interconvert redox energy and proton motive force across biological membranes using a variety of mechanisms.
[4] Sazanov is known for the discovery of the first atomic structure of respiratory complex I, using X-ray crystallography and the bacterial enzyme as a model.
[4] The complex I structure revealed many unexpected and unique features of this extravagantly elaborate membrane protein assembly.
Sazanov then went on to determine the first complete atomic structure of the even larger mammalian mitochondrial complex I, using new cryogenic electron microscopy methods.
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