[2][4] Cecotto was largely self-educated,[2] in part because her father forbade her to attend El Ateneo Paraguayo (the Paraguayan Athenaeum).
[2][7] As a result of her contributions, Cecotto is considered part of the Grupo Arte Nuevo, a school of influential 20th-century Paraguayan artists.
[8][2][9][10][11] Ceocotto was a founder of the Center de Artistas Plasticos del Paraguay, and taught drawing and painting at the Female Institute of Integrated Culture in Asuncion.
[2] In his 1984 book Una interpretación de las artes visuales en el Paraguay, Paraguayan art critic (and future Paraguayan minister of culture) Ticio Escobar noted of the artist;[2] Leonor Cecotto’s image is ‘naive’ in the literal sense of the term; it treats things with good faith and no reserve, directly and without malice.
Leonor’s painting follows a similar path as her printmaking and coincides with it at certain points; her disproportionate flowers with aggressive colors.. and her final oleo paintings, which include dolls and mannequins in situations characterized by foppishness, express, in different ways, this melancholic enchantment with the obvious and the trivial that characterizes Leonor’s oeuvre[2][a] Cecotto's work can be found in the Metropolitan Museum of Art, the National Library of France, the Art Museum of the Americas, in the collection of the University of Sydney, the Centro de Artes Visuales de Asunción, and in private collections.