Calvo-Sotelo was born into a prominent political family in Madrid on 14 April 1926 with his father, Leopoldo Calvo Sotelo,[1] and his mother, Mercedes Bustelo Márquez.

[2] The assassination of his uncle, José Calvo Sotelo, who had been finance minister under Miguel Primo de Rivera, was a key event leading up to the Spanish Civil War.

[2] Calvo-Sotelo was kept in the cabinet of Adolfo Suárez upon his succession to premiership in 1976 and directed several centre-right and centre-left political associations into one party, the Union of the Democratic Centre (UCD).

[2] Calvo-Sotelo was part of the Tacito group in the cabinet along with Eduardo Carriles, Andrés Reguera, Landelino Lavilla, Enrique de la Mata, Marcelino Oreja and Alfonso Osorio.

[2] After the resignation of Suárez on 29 January 1981, he was supposed to be appointed Prime Minister (Presidente del Gobierno) on 23 February, and advocated Spain's proposed entry into NATO as soon as possible.