Described by André Aptroot in 2002, Lepraria multiacida was identified in the Serra do Caraça [pt] in Minas Gerais, Brazil.

It has a cream to whitish colour, composed of irregular granules on a sometimes whiter or occasionally blackened medulla.

The medulla may predominantly consist of hyphae, forming a kind of base layer (hypothallus).

[2] Chemically, the thallus reacts K+ (yellow-orange) when treated with potassium hydroxide solution, but is unreactive to KC and C tests.

[2] Lepraria multiacida is locally common on natural sandstone outcrops as well as on walls and soils between boulders.