[1][2][3][4] Notice that similar common name "big-eyed tree frog" is sometimes used for Leptopelis vermiculatus from Tanzania[5] and for Litoria exophthalmia from New Guinea.

[6] Leptopelis macrotis is a large Leptopelis species: females measure 74–84 mm (2.9–3.3 in) in snout–vent length, while males are more modest at 40–46 mm (1.6–1.8 in) SVL.

[3][4] Its natural habitats are primary rainforests at elevations of 100–700 m (330–2,300 ft) above sea level.

However, because it relies on good (i.e., non-degraded) rainforest, habitat degradation caused by agricultural expansion, logging, and human settlements is a major threat.

The International Union for Conservation of Nature (IUCN) has assessed it as being "Vulnerable"—despite its large range, the actual area of occupancy is modest (about 236 km²), and its habitat is being lost.