Leptoxis is a genus of freshwater snails with a gill and an operculum, aquatic gastropod molluscs in the family Pleuroceridae.

Species within this genus inhabit rocky fast-flowing parts of unpolluted and unimpounded mid-sized rivers in the American mid South and the southern Midwest.

Species in the subgenus Mudalia inhabit rivers and creeks in the Atlantic drainage.

Species within the genus Leptoxis include:[2] Those that are extinct are marked with a dagger †.