The name of the town was shown as Lexovico in an 1821 map by the French writer and traveller François Pouqueville, and as Leskovik in an Ottoman document produced in 1851.

Ottoman Albanian spahis and landowners from 19th century Leskovik owned estate properties (chiftlik) in parts of the Balkans and in particular the Thessalian plain, until its loss to Greece in 1881 leading to local economic decline and increasing reliance on agriculture.

[13] A few Muslim Albanians from Leskovik were employed in the Ottoman bureaucracy as administrative officials governing some districts in parts of the empire.

Shortly after the town was visited by an international commission who was responsible to draw the precise borders between the Kingdom of Greece and the newly established Principality of Albania.

[19] During World War I in the summer of 1916 the town was occupied by Italian troops due to the pretext that the Greek forces could not resist the advance of the Bulgarian army in the Balkan front.

[20] At 21 November 1940, during the Greco-Italian War, units of the II Army Corps of the advancing Greek forces entered Leskovik after breaching the Italian defences.

The town also hosted a training, a supply center, as well as medical facilities for the communist guerrillas, who mounted several invasions from Albanian soil into the Greek region of Grammos and fled back to Albania once an operation was completed.

[23] Part of the Eastern Orthodox community consists of Aromanians that are found in mixed neighbourhoods in the town.

In around 2000, a number of Muslims, living in Greece but originally from Leskovik, and who had a Bektashi background, began work on restoring the tekke.

In the modern period, the town of Leskovik is religiously mixed, composed of Muslim Bektashis and Eastern Orthodox Christians.