Her Royal Highness Oheneba Lesley Akyaa Opoku Ware is a Ghanaian physician and diplomat.

Oheneba Lesley Akyaa Opoku Ware is the daughter of Victoria (née Victoria Nana Akua Afiiriyie Bando) and Otumfuo Opoku Ware II, the 15th King of the Ashanti Kingdom (Asantehene) hence the prefix of her name, "Oheneba".

She was still based in Moscow when she presented her credentials in Armenia to President Armen Sarkissian in January 2019.

The president, Nana Akufo-Addo, encouraged her and twenty other ambassadors or high commissioners to assist their country in recovery after the COVID-19 pandemic.

[9] As of 2021[update], she was ambassador to Armenia, Azerbaijan, Belarus, Kazakhstan, Moldova and Russia.