Leslie Marie Osborne (born May 27, 1983) is a retired American soccer defensive midfielder who last played for the Chicago Red Stars in the NWSL in 2013.

She is a former member of the United States women's national soccer team and previously played for FC Gold Pride and the Boston Breakers in the WPS.

As a senior in 2004, she was a semifinalist for the Hermann Trophy and won the Honda Sports Award as the nation's outstanding collegiate female player.

When the WPS suspended operations in early 2012 and later folded, Osborne continued with the Breakers as they moved into the Women's Premier Soccer League Elite.

After sitting out the first U.S. game of the 2007 FIFA Women's World Cup in favor of Shannon Boxx, she played all 90 minutes in all five remaining matches.