Lesparre-Médoc (French pronunciation: [lɛspaʁ medɔk] ⓘ; Occitan: L'Esparra de Medòc, [lespaˈra ˈde meˈðɔk]), commonly known as Lesparre (L'Esparra), is a commune in the Gironde department, Nouvelle-Aquitaine, southwestern France.

Traces of human occupation from the Neolithic era have been discovered in the town.

Before the arrival of the Romans, the area was inhabited by the Biturges, a Celtic tribe.

After the Roman Empire collapsed, various peoples such as the Arabs and Normans came into the area.

Lesparre is twinned with Drayton in the Vale of White Horse, Oxfordshire, England.