[1] Lesser Antillean iguanas are primarily herbivores, feeding on leaves, flowers, seeds, fruit, and growing shoots of upwards of 100 different species of plant.

[5][6] They are known to consume manchineel (Hippomane mancinella), a tree species that produces chemicals that are toxic to mammals and birds.

During the dry season (January to May), lesser Antillean iguanas tend to consume more foliage than fruit.

[1] The Lesser Antillean iguana is legally protected from hunting throughout its range, but enforcement of these regulations is extremely difficult and therefore limited.

Other threats include habitat loss to agriculture and development and the introduction of feral predators such as dogs, cats, and mongooses.

[7] In addition, the green iguana has been interbreeding with the Lesser Antillean iguana and this hybridization has been the number one reason for the latter species' decline on numerous islands (Basse Terre and Grande Terre (Guadeloupe), St. Barthélemy, Martinique) or complete disappearance (e.g., Les Iles des Saintes).

Following on from this success, 11 iguanas hatched at Durrell in 2016 and they will be sent to zoos across Europe in an effort to promote and support the urgent conservation work for this species.