"Let Me Hold You" peaked at number four on the Billboard Hot 100, making this the first top 10 hit for both Bow Wow and for Omarion as a solo artist.

The song was certified Platinum by the Recording Industry Association of America (RIAA) for selling over 1,000,000 copies.

A music video, directed by Bryan Barber, was made to promote the single and featured Bow Wow and Omarion hanging out at a house party.

"[1] The collaboration began when Bow Wow was talking with producer Jermaine Dupri about the song and how he suggested on getting Omarion to appear on the track.

He played him the Luther Vandross sample and was hesitant about his initial reaction at first before thinking it over and seeing its potential as a smash hit.

It features a sample of Luther Vandross' version of "If Only for One Night", written and originally performed by Brenda Russell.

AllMusic's David Jeffries put it alongside "Like You" as the album's highlights that work "on a more adult level.

"[4] Steve 'Flash' Juon of RapReviews praised the production by Dupri and No ID for their clever take on the sample, Bow Wow's lyrics and Omarion's guest vocal performance.

[16] On May 14, 2006, "Let Me Hold You" was certified Platinum by the Recording Industry Association of America (RIAA) for selling over 1,000,000 copies in the United States.

[17] The song's music video, directed by Bryan Barber, features Bow Wow attempting to woo a girl with mixed results.