[6] According to the Trans-Canada Air Lines (TCA) system timetable dated January 1, 1940, Lethbridge was a stop on Trans-Canada's transcontinental flights linking Montreal, Ottawa, Winnipeg, Regina and Vancouver with connecting service to and from Toronto via North Bay (which was one of the stops on the TCA transcontinental flights between Montreal and Vancouver) operated with Lockheed piston engine twin prop aircraft.

[8] Western operated Boeing 247D twin prop aircraft with a routing of Lethbridge-Cut Bank-Great Falls-Helena-Butte-Idaho Falls-Pocatello-Salt Lake City.

Since land was required for gunnery and bombing practice, about 100 sq mi (260 km2) was leased from the Blood Indian Reserve located nearby.

In February 1976, the Official Airline Guide (OAG) listed up to eight round trip flights a day operated by Time Air nonstop between Lethbridge and Calgary with Fokker F27 Friendship and de Havilland Twin Otter turboprops.

According to the November 15, 1979 edition of the OAG, Time Air was operating up to ten flights a day nonstop to Calgary with DHC-6 Twin Otter and Short 330 turboprop aircraft.

[12] By April 1985, the airline was operating larger Dash 7 turboprops on the Lethbridge-Calgary route in addition to the Short 330 aircraft with up to nine flights a day.

[13] In 1995, Time Air was flying the Fokker F28 twin jet on a daily basis between Calgary and Lethbridge in addition to other flights operated on the route with Dash 8 turboprops.

[17] On July 26, 2009, the Evergreen Supertanker successfully landed and took off from runway 05 as part of the 2009 airshow, marking the first time a Boeing 747 has used the airport.

[21] The airport is a Canadian Air Transport Security Authority (CATSA) Designated Aerodrome, thus providing full passenger screening.

It also serves as a regional airport, offering a number of on-site charter, maintenance, flight training and specialty aviation services.

[citation needed] There are roughly 40 aircraft based at the airport, including commercial, corporate, recreational, flight training, aerial spray and rotary-wing.

[citation needed] Both offer Avgas 100LL, Jet A1 FSII, GPU, de-icing, a pilot lounge, hangarage, and tie downs.

[24] On July 23, 2010, a Royal Canadian Air Force McDonnell Douglas CF-18 Hornet crashed during a practice run for the upcoming Alberta International Airshow.