[1] Two years later, the Knights won their first senior basketball title under coach Jacinto Ciria Cruz and team captain Felicisimo Fajardo[1] by beating San Beda, 42-30.

In 1960 the team, which were led by Clemente Bargas, Augusto Cepeda, bigman William Jance, and rookies Freddie Webb and Basilio Go, faced the Jose Rizal Heavy Bombers in the championship round at the Araneta Coliseum.

[4] They finally clinched the championship, thanks to Basilio Go's game-winning jumper from the free throw area to win the game, 75-73, thus ending a ten-year title drought.

[1] Later in 1966, the Knights, coached by Nilo Verona and were led by Larry Albano, Nemie Villegas, Augusto Fermin, and Eddie Reyes, beat the much taller Heavy Bombers for the championship.

[1][5] In the 1970 season, the Knights, led by Molet and Ricky Pineda, Rudy Hines and bigman Dave Regullano, beat the De La Salle Green Archers, for the championship.

Coached by the legendary Nemie Villegas, and led by Most Valuable Player (MVP) Ramon San Juan, shooting forward Angelito "Itoy" Esguerra, spitfire Pedrito "Bong" Aninon, Timoteo "Tim" Coloso, Nonito "Nonie" Robles, and team captain Ed Baldomero, the Knights defeated the Leo Isaac-led Cardinals to take home the school's 6th championship.

[6] The Letran Knights started the 1982 season under the tutelage of new coach Larry Albano which featured a very exciting player named Avelino "Samboy" Lim, a product of San Beda's high school program.

The Knights were unofficially crowned champions but they still had to play Trinity College in a no-bearing game to officially finish their NCAA campaign.

[8] In 1983, Samboy Lim and the Knights advanced to the championship round where they will meet Nani Demegillo and the San Sebastian Stags for the title.

[10] In 1985, hopes for a rare four-peat vanished as the Knights succumbed to the Stags in the Finals as they lost five of its key players, notable of which was Samboy Lim.

In 1986, Letran won the 2nd round eliminations to arrange a championship match again with the defending champions San Sebastian, led by "Mr.

In 1987, the Letran Knights swept the 2nd round eliminations to secure a spot again in the Finals to face their rivals San Sebastian Stags in a best-of-three series.

Led by season MVP Ronald "Joy" Peña, Gilbert Castillo, and Wilmon Yu, the Knights defeated the Stags in three games.

A power outage hit the area with 42 seconds left and Letran students and supporters poured onto the court for an early celebration while waiting for the lights to be restored.

In 1998, the Knights, led by Kerby Raymundo and season MVP Chris Calaguio, and now coached by Louie Alas, faced the sixth-peat seeking Stags in the Finals.

The Letran Knights went to the best-of-three Finals to face the JRC Heavy Bombers, led by Ernani Epondulan and Ariel Capus.

In 2002, former mentor Louie Alas came back as the head coach of the Knights after his stints in Manila Metrostars in the MBA, and the Mobiline Phone Pals in the PBA.

The 2003 series culminated with a play-off between the Letran Knights and the hosts, the San Sebastian Stags, who had won the previous two championships.

The Knights, led by Ronjay Enrile, were aiming to break Ateneo de Manila University's record of 14 titles.

In the final minutes, Boyet Bautista, Aaron Aban and Jonathan Piñera ignited an 8–0 run, turning a 56–58 deficit into a 64–58 title-clinching victory.

In 2010, the Knights failed to advance to the Final 4 for the second time in the Louie Alas era but 2 weeks after the tournament they started their preparation for Season 87.

In 2011 the team was joined by Kevin Racal, JRU transferees Joel Gabriel and Carlo Lituania, and spitfire point guard Mark Cruz and Zyron Cudal from the Letran Squires program.

[34] The Knights finally ended its ten-year title drought as they captured their 17th NCAA men's basketball championship by beating San Beda in three games.

[35] Just weeks after leading the Knights to a championship, Aldin Ayo left Letran to coach the De La Salle Green Archers in the UAAP citing personal reasons.

[46] In that year, UST Growling Tigers players Rhenz Abando, Brent Paraiso, and Ira Bataller formally transferred to Letran.

[47] When the NCAA men's basketball finally resumed in the second semester of the academic year 2021-22,[48] the Knights finished the elimination round at first place with an unblemished record.

[49] Letran then eliminated UPHSD and entered the Finals and faced their Intramuros neighbors the Mapúa Cardinals and defeat them in two games to successfully defend and capture their 19th basketball title.

[51] After leading the Knights to the NCAA Season 97 title, Rhenz Abando decided to forego his final playing year to pursue his basketball career as a professional player.

[52] Even without the presence of their MVP, the Knights, still bannered by team captain Fran Yu, Louie Sangalang, and Brent Paraiso, successfully defended and captured its 20th NCAA basketball championship, and their third consecutive title, by beating the number one seeded Benilde Blazers in three games.

[54] A month later, multi-titled mentor Bonnie Tan stepped down as head coach of the Knights to focus on his duties as the main tactician of the NorthPort Batang Pier in the PBA.