It also serves as the final stop in the Republic on Route 64 from Galway via Sligo, though the bus service continues from there in a north-easterly direction before turning south-eastwards towards Killea and eventually crossing the border into Northern Ireland.

Short-term parking spaces are located close to the station building, though vehicles do not have access to the area where buses load their cargo.

Taxis are located a short distance away (close to the easily visible sign for Michael Murphy Sports and Leisure), though can be called across by telephone if necessary.

The station building, designed by architectural firm Quinn Architects, houses ticket counters, ticket machines, noticeboards, and waiting areas (both standing and seated) in addition to passenger amenities, such as restrooms, lighting and radiators.

In 1996, Minister for Transport, Energy and Communications Michael Lowry announced he had acquired EU funding under the Interreg programme for several Bus Éireann stations, including the one in Letterkenny, with the station set to get a passenger waiting area, toilets for the handicapped and facilities for crews, vehicle storage and shelters among other things.