He has a multi-decade history in American political fundraising circles and has held a number of national, state, and bi-state appointments throughout his career, including serving as the chairman of the Port Authority of New York and New Jersey[1] at the time of the September 11, 2001 attack of the World Trade Center, which the Port Authority operated.

In July 2017, Eisenberg was named as President Donald Trump's nominee to become the United States Ambassador to Italy.

He served on the board of ITC, the nation's largest independent electric transmission business and a former KKR portfolio company.

[citation needed] Eisenberg served as a senior advisor for Kohlberg Kravis Roberts[9] beginning in 2009.

Working alongside co-founders Henry Kravis and George R. Roberts, Eisenberg provided enhanced investment expertise particularly in the public infrastructure arena.

Prior to his election as chairman, Eisenberg had served since February 1994 as a commissioner on the same agency's board, having been nominated by Governor Christine Todd Whitman.

During his term as chairman, his most notable achievement was the negotiation of a long-term lease with Larry Silverstein for the World Trade Center;[10] the Towers were at their highest occupancy in history in the late 1990s[11] and the desire to privatize the buildings was born from an economic strategy of the Pataki administration.

It was during his time as chairman that the September 11, 2001 terrorist attacks occurred at the Twin Towers, taking the lives of 84 Port Authority employees including then executive director Neil Levin.

Eisenberg served on the advisory council of Samuel Johnson Graduate School of Management at Cornell University, and was a board member of St. Barnabas Health Care System and past chairman of its investment committee.