Lewis University was founded in 1932 by the Archdiocese of Chicago and Bishop Bernard J. Scheil as the Holy Name Technical School.

In 1935, it became Lewis Holy Name School of Aeronautics, a name which is engraved in stone on the building now known as the Philip Lynch Theatre at the Oremus Fine Arts Center.

During World War II, normal classes were suspended as the campus was given to the United States Navy to train pilots.

The university is a member of the Division II level of the National Collegiate Athletic Association (NCAA), primarily competing in the Great Lakes Valley Conference (GLVC) for most of its sports since the 1980–81 academic year; while its men's volleyball team compete in the Midwestern Intercollegiate Volleyball Association (MIVA).

Lewis competes in 24 intercollegiate varsity sports: Men's sports include baseball, basketball, bowling, cross country, golf, lacrosse, soccer, swimming, tennis, track & field and volleyball; while women's sports include basketball, bowling, cross country, golf, lacrosse, soccer, softball, stunt, swimming, tennis, track & field and volleyball.