The site, located in Hartford, Illinois, commemorates Camp River Dubois, the camp of the Lewis and Clark Expedition from December 1803 to May 1804.

The site is at the southern end of the Meeting of the Great Rivers Scenic Route.

The Lewis and Clark State Historic Site is situated on the dry side of the Chain of Rocks Levee, approximately 0.25 miles (0.40 km) from the Illinois shore of the Mississippi River.

Main attractions at the site include a 14,000-square-foot (1,300 m2) interpretive center and an outdoor replica of Camp River Dubois.

[1] The interpretive center contains a theater, multiple hands-on exhibits and displays, and a 55-foot (17 m) full-scale cutaway keelboat.