In this area that would later become majority Pennsylvania German, the first and second waves of settlers were almost entirely English speakers and included the Kirks, Rankins, Huttons, Garetsons, Nebingers, Eppleys, Starrs, Fosters, Clines, Stromingers, Moores, Frankelbergers, Suttons, Wickershams, Prowells, Millers, and Hammonds.

Lewis and members of other prominent families in the area served in the Pennsylvania militia, and Eli rose to the rank of major.

Following the Revolutionary War, Lewis' fortune grew (and he eventually owned 850 acres in the area) and his store was the center of commerce in the Redland Valley.

In 1798, Issac Kirk surveyed twelve acres of land and laid out lots for Lewis, who wanted a town to exist on the site.

In 1800, Henry Ensminger opened a large tannery just south of town that was later owned and operated by Samuel Grove.

More significant for the town's growth was John Herman, who built a large flour mill on the west side of the borough.

One of Lewisberry's most important small industries during the 19th and early 20th centuries was the manufacture of block brimstone matches, and the families of Lyman Lewis, Herman Kirk, Moses Magrew, Rt.

This industry grew under his children, and by the middle of the century, Lewisberry was producing large numbers of coffee grinders in a small factory near the Quaker meeting house.

[5] According to the United States Census Bureau, the borough has a total area of 0.1 square miles (0.26 km2), all land.

The intersection of Pennsylvania Route 177 and Pleasant View Road near the borough is said to allow an automobile in neutral to drift uphill.

According to legend, this effect is caused by the ghosts of children once killed in a bus accident, who push the car uphill to prevent similar occurrences.