Lewisburg is a village in Preble County, Ohio, United States, founded in 1818.

In 1833, Lewisburg contained one Lutheran church, four stores, two taverns, two physicians, one botanical practitioner, two merchant mills, forty dwelling houses, and about 200 inhabitants.

In about 1836, pioneer John Mumma founded the community of Euphemia, named for his wife, to the north of Lewisburg on the National Road.

The villages officially merged on April 4, 1916, and the combined community retained the name of Lewisburg.

[5] According to the United States Census Bureau, the village has a total area of 1.07 square miles (2.77 km2), all land.

21.2% of all households were made up of individuals, and 11.8% had someone living alone who was 65 years of age or older.

Major employers in Lewisburg, Ohio, include Cheeseman Trucking,[9] Parker Hannifin Corporation,[10] the Tri-County North School District,[11] the Iams Corporation, which has a manufacturing plant and research center located nearby,[12] Promivi North America Inc., which was previously known as the Carl S. Akey Corporation,[13] and Lewisburg Container.

According to the Ohio Department of Education [15] Tri-County North received an Excellent rating for the 2010-2011 school year.