It was added to the National Register of Historic Places in 2004.

Notable buildings in this district are: the Derr House (1773), nineteenth- and early-twentieth-century Bucknell University buildings, including Old Main and Bucknell Hall, the Union County Courthouse (1856), the U.S. Post Office and Court House (1933), Himmelreich Library (1902), the First Presbyterian Church (1856), Christ Lutheran Church (1901), Union National Bank (1899), the McClure Building (1913), Campus Theatre (1941), and the Buffalo Mills (1883).

[2] Also located in the district are the separately listed Chamberlin Iron Front Building, Packwood House-American Hotel, and Reading Railroad Freight Station.

Contributing sites are the Lewisburg Cemetery and Soldiers Memorial Field.

[2] It was added to the National Register of Historic Places in 2004.