[10] Zimmerly Air Transport began scheduled service in 1944 at Lewiston,[11][12] flying intrastate routes in Cessna Airmasters, and then became Empire Airlines in 1946,[13] and moved to Boeing 247 prop aircraft.

[21] Republic's final flight to Lewiston was in September 1982,[22][23] and the airline ended its southern Idaho and eastern Washington service the following April.

[27][28] According to the Official Airline Guide (OAG), Cascade was operating international service of a sorts into the airport in early 1985 with a direct flight once a week from Calgary via an intermediate stop in Spokane.

According to the Official Airline Guide (OAG), the only airline serving Lewiston in the spring of 1975 was Hughes Airwest with four daily jet flights, three operated with the McDonnell Douglas DC-9-30 and one operated with the smaller Douglas DC-9-10, with nonstop service from Boise (BOI) and Spokane (GEG), one stop service from Salt Lake City (SLC), Seattle (SEA) and Twin Falls, ID (TWF), and direct no change of plane service from the John Wayne Airport (SNA) in Orange County, CA as well as direct from Phoenix (PHX) and Tucson (TUS) in Arizona.

[46] The Official Airline Guide lists two airlines serving Lewiston in early 1985 including Cascade Airways operating British Aircraft Corporation BAC One-Eleven jets and Beechcraft 1900C turboprops with nonstop service from Boise (BOI), Pasco, WA (PSC), Pullman, WA (PUW), Seattle (SEA), Spokane (GEG) Walla Walla, WA (ALW) and Yakima (YKM), and Horizon Air operating as an independent air carrier with nonstop Fairchild Swearingen Metroliner turboprop service from Boise (BOI) Pasco (PSC), Pullman (PUW), Seattle (SEA) and Spokane (GEG).

[47] The OAG lists a combined total of 20 flights every weekday operated by the two airlines into the airport at this time primarily flown with small commuter propjet aircraft.

[49] The OAG lists a combined total of 27 flights every weekday operated by the two airlines into the airport at this time, all flown with propjet aircraft.

[1] In the year ending January 1, 2012, the airport had 35,425 aircraft operations, average 97 per day: 77% general aviation, 13% air taxi, 8% airline and 2% military.