It connects Interstate 190 in the town of Lewiston, New York to Highway 405 in the community of Queenston, Ontario.

Customs plazas are located on both ends of the bridge, with tolls only being charged on entering Canada ($5.00 USD or $6.50 CAD per passenger automobile).

Canadian and United States flags fly at the midpoint on the south side of the bridge.

[citation needed] It is on the most direct route connecting the US Interstate system to Toronto and Detroit.

The United States announced plans in 2016 to spend US$50 million to upgrade the primary inspection facilities.

Newspapers reported that bridge deck had been destroyed in February 1864 by wind which caused main deck to sway excessively due to earlier removal of stabilizing guy-wires by local authorities, however main suspension cables remained fully intact.

The suspension bridge design was unusual because the cables were attached to the cliff with only small towers.

The supports are part of Owen Morrell's Omega, a steel sculpture and observation platform added in 1981.

To protect people in the city, the pilot steered it into the Niagara River gorge before safely ejecting; but this aimed it near the construction site.