The station is actually located across the Juniata River from Lewistown proper, a little less than one mile south of the center of the borough.

It is currently only served by Amtrak's Pennsylvanian, which operates once per day in each direction, though until 2005, Lewistown was served by a second daily train, the Three Rivers (a replacement service for the legendary Broadway Limited), an extended version of the Pennsylvanian that terminated in Chicago.

Upon its cancellation, the sole Pennsylvanian marked the first time in Lewistown's railway history that the town was served by just a single, daily passenger train.

The station house, according to volunteers that staff it, is the oldest structure built by the Pennsylvania Railroad which is still standing.

Operations were moved into the freight station, while the old brick building became a hotel, restaurant, and a Railway Express Agency.