Before joining the second-largest television market in the nation, Nguyen was a news anchor and reporter for NBC-affiliate KCRA-TV in Sacramento, California, where she also hosted a quarterly program on Asian-American issues.

She appeared in over 30 television shows and movies such as NCIS: Los Angeles, Boston Legal, Two and a Half Men, Pushing Daisies, Austin Powers in Goldmember, The Day After Tomorrow, and Teenage Mutant Ninja Turtles.

She hosted the annual Jerry Lewis Labor Day Telethon with entertainer Casey Kasem, and the Southern California Special Olympics Summer games, with Hall of Famer James Worthy.

Since 2020, Nguyen has produced and hosted a podcast about non-monogamy, swinging, cuckolding, and other alternative sexual lifestyles called Consenting Adults.

Nguyen has a non-profit foundation called "Love Across the Ocean", which benefits underprivileged school children in Vietnam and assists refugees in Southern California.