[3] In 1838, only three years after the first continental railway, a line linking Brussels and Ans, in the northern suburbs of Liège, was opened.

The Guillemins site, located slightly outside the city centre, was chosen for technical reasons over the local preference for the Place Saint-Lambert.

In 1843, the first international railway connection was born, linking Liège to Aachen and Cologne (Germany).

Its massive structure and its large French-style fan-shaped canopy illuminating the waiting room were its pride.

At the end of the 20th century, high-speed trains were introduced, requiring a new station since the existing platforms were too small.

The new station, by the Spanish architect Santiago Calatrava, was officially opened on 18 September 2009, with a show by the stage director Franco Dragone.

[7] In June 2024,[8] the Liège-Guillemins to Maastricht service by National Railway Company of Belgium train line will be replaced by an Arriva service but will be staffed by National Railway Company of Belgium personnel through the Belgian border.

Liège-Guillemins is also a transport hub for TEC Bus: more than 1620 buses, carrying 15,000 people, serve the station every day.