He played the roles of Josh Taylor in the soap opera Neighbours and Marcus in the children's television series The Elephant Princess.

[9] He attended his first audition at the age of sixteen[12] and began his career in 2007 with guest appearances on the TV shows Home and Away and McLeod's Daughters.

[13] The week of 8 July 2007, Hemsworth began filming episodes for Neighbours, an Australian soap opera his brother Luke had previously starred in.

In the show, Josh was an athletic paraplegic who supported and began a relationship with character Bridget Parker after she was paralysed down one side of her body in a car crash.

[15] In 2008, Hemsworth began acting on the children's television show The Elephant Princess, playing "Marcus", the lead guitarist of the protagonist's band.

[10] Though he eventually lost the role to Chris in May,[11] Disney announced later the same week that Hemsworth had landed the part of Will Blakelee in the 2010 drama The Last Song, based on the Nicholas Sparks novel by the same name.

[20] In September 2009, Hemsworth appeared at a dinner event to promote Foxtel, an Australian pay television company.

[17] Later that month, it was announced that Hemsworth was in negotiations to star in Arabian Nights, a 3D action film that will be directed by Chuck Russell for Inferno Entertainment.

[23] He has also reportedly been offered the lead role in Northern Lights after Taylor Lautner withdrew from the David Ellison-financed project.

[27] In 2013, Hemsworth appeared in Empire State, with Emma Roberts, and Paranoia, co-starring Harrison Ford, Gary Oldman and Amber Heard.

[28] In 2015, Hemsworth portrayed the love interest of Kate Winslet's character in the Australian literary adaptation The Dressmaker, which was filmed in Victoria in the summer of 2014.

[33] In October 2022, Netflix announced that Hemsworth would be replacing Henry Cavill as Geralt of Rivia from the start of Season 4 of The Witcher.

[42] Rumours began in January 2016, stemming primarily from sightings of the couple together at his Malibu home and the reappearance of the engagement ring on Cyrus’s finger.

[47][48][49] In his posts he praised the residents of his community on how they united in helping with the consequences of the fire, and encouraged his followers to donate their time, money, and resources to The Malibu Foundation, a non-profit established in the wake of the Woolsey fire, and to his fiancée's own non-profit organisation, the Happy Hippie Foundation, to further contribute help with the aftermath.