The species is endemic to Indonesia, East Timor, Papua New Guinea, and coastal northern Australia.

[3] The specific name, mackloti, is in honor of naturalist and taxidermist Heinrich Christian Macklot.

[4] Attaining 7 ft (2.13 m) or more in total length (including tail), Macklot's python is large and if not treated properly can be a poor-tempered snake.

[3] Liasis mackloti is found in Indonesia in the Lesser Sunda Islands of Savu, Roti, Samao, Timor and Wetar, in East Timor, Papua New Guinea, and coastal northern Australia.

[1] Liasis mackloti is a snake that is known and sold in the live exotic animal trade, bringing it far beyond its native range, to as far as the United Kingdom, and North America, where it is sold and kept in captivity from pet stores, speciality shops, and conventions.