Cities and towns are marked in bold and market towns in italics: Bílá - Bílý Kostel nad Nisou - Bílý Potok - Bulovka - Černousy - Český Dub - Cetenov - Chotyně - Chrastava - Čtveřín - Dětřichov - Dlouhý Most - Dolní Řasnice - Frýdlant - Habartice - Hejnice - Heřmanice - Hlavice - Hodkovice nad Mohelkou - Horní Řasnice - Hrádek nad Nisou - Jablonné v Podještědí - Janovice v Podještědí - Janův Důl - Jeřmanice - Jindřichovice pod Smrkem - Kobyly - Krásný Les - Křižany - Kryštofovo Údolí - Kunratice - Lázně Libverda - Lažany - Liberec - Mníšek - Nová Ves - Nové Město pod Smrkem - Oldřichov v Hájích - Osečná - Paceřice - Pěnčín - Pertoltice - Příšovice - Proseč pod Ještědem - Radimovice - Raspenava - Rynoltice - Šimonovice - Soběslavice - Stráž nad Nisou - Světlá pod Ještědem - Svijanský Újezd - Svijany - Sychrov - Višňová - Vlastibořice - Všelibice - Žďárek - Zdislava Liberec District borders Poland in the north and briefly Germany in the northwest.

The terrain is very diverse, with large differences in altitude, and hilly landscape prevails.

The territory extends into seven geomorphological mesoregions: Frýdlant Hills (north), Jizera Mountains (east), Zittau Basin (centre), Ještěd–Kozákov Ridge (a strip from centre to southeast), Jičín Uplands (south), Ralsko Uplands (southwest) and Lusatian Mountains (a small part in the west).

It includes the Czech part of the UNESCO World Heritage Site named Ancient and Primeval Beech Forests of the Carpathians and Other Regions of Europe.

The largest employers with headquarters in Liberec District and at least 1,000 employees are:[5] A short section of the D10 motorway from Prague, which further continues as the R/35 expressway to Liberec and Chrastava (part of the European route E442) and then forks to the I/13 road to Děčín and to the I/35 road to Zittau, runs through the district.