[1] Griffin committed to play college football at Mississippi State over other schools such as Auburn, Tennessee, and Memphis.

[5] In week two of the 2021 season, he returned the opening kickoff 100 yards for a touchdown, as he helped the Bulldogs beat NC State.

[8] In week ten, Griffin returned a kickoff 92 yards for a touchdown and hauled in a 57-yard reception as he helped the Bulldogs defeat Auburn 39–33 in overtime.

[14][15] Griffin was named preseason second-team all-SEC ahead of the 2023 season as an all-purpose back and third team as a returner.

[18][19] Griffin would also be named to the Paul Hornung Award watch list, which is give to the nation's most versatile player.