LifeSiteNews was founded in 1997 by the Canadian political lobbyist organization Campaign Life Coalition with the intent to promote anti-abortion views.

The goal of the conference is to provide an interactive experience for all forum participants as we work together to formulate a plan to end corruption in the church, which will ultimately end corruption in the world.At the forum Joseph Strickland made a speech following which Pope Francis removed him from his post as bishop for the Diocese of Tyler, Texas, US.

[9] It also regularly publishes articles expressing opposition to contraception, homosexuality,[10] and transgender rights,[11][12] and its website names euthanasia and cloning among other issues it opposes.

[6] In August 2018, The Advocate reported that LifeSiteNews was publishing articles linking the Catholic Church sexual abuse cases to homosexuality.

[11] Political Research Associates analyst Heron Greenesmith categorized LifeSiteNews to NBC News in September 2019 as a member of the "Christian-right anti-transgender disinformation ecosystem" and stated, "LifeSite platforms the small number of anti-trans researchers, academics, and right-wing professional associations, giving their work a veneer of scientific validity".

[12] Brennan Suen of the watchdog group Media Matters for America said that LifeSite "typically refuses to acknowledge transgender identities and serially misgenders trans folk in its coverage", and that it "refers to the abhorrent practice of conversion therapy as treating 'unwanted homosexual attraction.

'"[11] Moses wrote in Commonweal that the site spread confusion about COVID-19, and that their coverage "is so slanted that anyone relying on it would be terribly misled on what the science shows".

[9][26][27] The site has published misleading claims about Donald Trump's attempts to overturn the results of the 2020 presidential election and articles supportive of the "Stop the Steal" campaign with the same goal.

They added that they believed Facebook should have banned the group "years ago" for using the platform to "push its noxious anti-LGBTQ and anti-choice extremism".