[4] Told from the personal point of view of Sam, his parents, and other families suffering from the effects of progeria, the documentary raises awareness on this currently incurable disease.

As stated in the film, progeria is an extremely rare and fatal genetic disease also referred to as premature aging syndrome.

Experimenting with a drug being used for similar protein abnormalities, Lonafarnib, Leslie meets other children with progeria to conduct clinical trials that would last two years and a half.

Since the number of progeria patients is so limited and treatment was a matter of ethics, Leslie made a critical decision that would lead to issues concerning earning a publication of the study from a peer-reviewed journal.

According to Los Angeles Times, Sean Fine claimed that they thought the trials would be finished in a year, but "(they) didn't realize how hard it is to get a scientific paper published.

[6] Dorothy Rabinowitz, of The Wall Street Journal, comments, "... nothing in this documentary equals the portrait of the unforgettable son they produced.

Moved by the inspirational approach that Sam and his family took upon his diagnosis, the bottom line quote for The Hollywood Reporter was posted as, "Wise and uplifting film about one young boy's graceful resilience against a rare terminal disease.

"[9] Robert Kraft, the owner of the New England Patriots, saw the film at the premiere in New York City and met Sam at a team practice.