The production on the album was handled by multiple producers, including Mike Dean, Mustard, Metro Boomin, Allen Ritter, Hit-Boy, Cardo, and Sonny Digital, among others.

The album also features guest appearances from Travis Scott, Kali Uchis, Baby Keem, HVN, and SoFaygo.

[3] Toliver's Cactus Jack Records label boss, American rapper and singer Travis Scott, teased his excitement and involvement in the album in a tweet on April 9.

[8] The second single, "Drugs n Hella Melodies", featuring Toliver's girlfriend, Colombian-American singer Kali Uchis, was released on June 18, 2021.

[10] Life of a Don debuted at number two on the US Billboard 200 chart, earning 68,000 album-equivalent units, (including 18,000 copies in pure album sales) in its first week.