The blog posts cover a wide range of topics including Microsoft Windows, Macintosh, Linux programs, iOS, and Android, as well as general life tips and tricks.

Gina Trapani founded Lifehacker and was the site's sole blogger until September 2005, when two associate editors joined her, Erica Sadun and D. Keith Robinson.

Other former associate editors include Wendy Boswell, Rick Broida, Jason Fitzpatrick, Kevin Purdy, and Jackson West.

Lifehacker's frequent guest posts have included articles by Joe Anderson, Eszter Hargittai, Matt Haughey, Meg Hourihan, and Jeff Jarvis.

On 1 January 2016, Whitson Gordon left Lifehacker for another popular technology website, How-To Geek, replacing editor-in-chief Lowell Heddings.

[5] In his January 2016 announcement, Gordon confirmed that Alan Henry would take over as the interim editor pending interviewing processes.

[9][10] In November 2023, as part of a brand refocus after the acquisition, Lifehacker updated with a new logo, a new site layout, and migration away from the Kinja platform.