The central part of the district belongs to the drainage basin of the Medveditsa River.

In 1238, the Mongols were advancing from Bezhetsk towards Tver and engaged in a battle with Slavs at the banks of the Medveditsa, currently within the area of the district.

Likhoslavlsky District, with the administrative center in Likhoslavl, was established within Tver Okrug of Moscow Oblast.

On July 23, 1930, the okrugs were abolished, and the districts were directly subordinated to the oblast.

[12] The main agricultural specialization of the district is cattle breeding with meat and milk production.

[13] The railway connecting Moscow and Saint Petersburg crosses the southwestern part of the district.

In Likhoslavl, a railway branches west and leads to Torzhok and further to Ostashkov and Rzhev.

The district contains seven cultural heritage monuments of federal significance and additionally fifty objects classified as cultural and historical heritage of local significance (seven of them located in Likhoslavl).

[15] In Likhoslavl, there is a local museum mostly devoted to Tver Karelian culture and ethnography.