[3][6] Lil Bub had an extreme form of feline dwarfism that caused her limbs and lower jaw to be quite small in comparison to the rest of her body.

[10][11] In late 2012, during the filming of Lil Bub & Friendz, she had a serious health episode and was diagnosed with osteopetrosis by a specialist in Indianapolis.

[16][17] Bridavsky sold a variety of merchandise under the LIL BUB moniker and donated much of the profits to animal rescue groups.

[3] Bridavsky has a policy to not "approach anybody for anything" and chose to not sign with talent agent Ben Lashes, whose clients have included Grumpy Cat.

[3] In May 2021, Bridavsky released a visual history coffee table book, Lil BUB: The Earth Years, with author Aaron Tanner.

[14] A screening of Lil Bub & Friendz at Metro Chicago raised $1,800 for Tree House Humane Society.

[23] Lil Bub posed for a PETA campaign that encouraged people to spay and neuter their pets in 2013.

[9][10][25] Lil Bub appeared in the YouTube Big Live Comedy Show with Jack McBrayer and the cast of Workaholics.

[32] Lil Bub's life story was featured for 30 minutes during the three hour "Animal Special" episode of the Japanese TV show Experience a Miracle – Unbelievable.

[38] Lil Bub, Bridavsky, Capper and Eisner attended the Tribeca Drive-In outdoor screening at the World Financial Center Plaza on April 20.

[18] The talk show format was made possible by having a subtitled Lil Bub edited with footage of her guests recorded separately.

[43] The episode ended with Lil Bub introducing the audience to Tabby's Place, a cat sanctuary for disadvantaged felines.