The following year, Lil' Mo appeared alongside Nas, Eve, and Q-Tip on Elliott's 1999 single "Hot Boyz".

On June 29, 1998, Mo released her debut single "5 Minutes" from the soundtrack for the Frankie Lymon biographical film Why Do Fools Fall in Love.

In August 2001, Mo released the follow-up single "Gangsta (Love 4 the Streets)", however, it failed to match the success of its predecessor.

[18][19] The album was scheduled for an early 2005 release, before being pushed back to October, after its four singles (including "Hot Girls" and "Dem Boyz") failed to create any buzz.

[21] On August 28, 2007, Mo released the album Pain & Paper, distributed by Koch Entertainment and DrakeWeb Music Group and selling only 6000 copies.

In 2008, Mo signed a two-album deal with Global Music Group and began work her fourth album, tentatively titled Tattoos & Roses: The Rebellion Against My Pain.

[23][24] In 2013, Mo became a cast member of the reality television series R&B Divas: Los Angeles, which premiered on TV One on July 10, 2013.

[25] The season's reunion special garnered a total of 834,000 viewers, tying with the debut of the sitcom The Rickey Smiley Show as the network's No.

[29][30] The album was preceded by the single "Should've Never Let You Go", as well as her second mixtape No Shit Sherlock, which featured contributions by Da Brat and songwriter Tiyon "TC" Mack.

In January 2016, Mo began hosting the WKYS radio show The Fam in the Morning with DJ Quick Silva.

[32] Later that year, Mo joined the cast of VH1's Love & Hip Hop: New York and appeared in an episode of Couples Court with the Cutlers.

[34][35] She was bludgeoned in the head by the man's champagne bottle and was immediately hospitalized at California Pacific Medical Center, where she received 20 stitches.

[34] Mo confirmed to MTV News that she had to cancel many shows and cease a double-music video shoot for her single "Gangsta" so she could recover from the incident.

Through the marriage, she became the stepmother to his son, Jerez Coleman, who in June 2014 appeared as "Kidd Cole" on an episode of MTV's television series Catfish: The TV Show.

In a 2017 episode of Love & Hip Hop: New York, Mo revealed that she had converted to Islam three years prior as a result of her marriage to Karl, and is seen praying in hijab.

In January 2003, while co-hosting 106 & Park: Prime, Mo sent a shout-out to 50 Cent, just seconds after she premiered a Ja Rule video.

[46] The incident angered Ja Rule and Murder Inc.[46] Mo had told the press she assumed BET was going to edit out the shout, and did not think the gesture would cause an uproar.

[46] Ja Rule released the diss track "Loose Change," which targeted Eminem, 50 Cent, Dr. Dre, Chris Lighty and Lil' Mo.

[54][55] The feud between Lil' Mo and R&B singer Keyshia Cole originated in August 2005 via the radio series Star and Buc Wild Morning Show.

Cole took offense and went to Dream Hotel in New York City, where she encountered Lil' Mo's manager Phil Thornton and a stylist, allegedly stating "You all are traitors.