[4][7] As of 2001, it spread as far west as Alberta, and as of 2017 full infestations reported as far north as the Edmonton, AB area.

[7] The larvae feed for up to 24 days, beginning underneath the leaf then working up the rest of the plant, and cause the most damage.

[11][7] Often the first evidence of lily leaf beetle infestation is sticky brown frass piles containing larvae on leaves.

[12] An adult that senses danger displays a defense mechanism, thanatosis, becoming motionless, folding up its appendages and falling with its black under surface facing up, thereby helping it camouflage with the ground to get away.

[13] This process is known as stridulation and could even shock a bird or any other predator that may attack the lily leaf beetle.

Other garden plants affected include Convallaria majalis, Polygonatum, potato (Solanum tuberosum), flowering tobacco (Nicotiana), hollyhock (Alcea) and Hosta.

[7] Fritillaria and Lilium specimens in Canadian gardens, particularly around Halifax, Nova Scotia are significantly affected by the lily leaf beetle.

[15] Products based on neem extracts are useful in killing very young larvae and repelling adults without comparable harm to other insects, although this option is perhaps less effective than handpicking.

[15] Floating row cover has been effective in preventing the adults from feeding and laying eggs in the spring.

[16][17] In Europe, total parasitism rate in the last instar stage averages about 90% on wild Lilium martagon, 75% in gardens and 60% in cultivated lily fields.

Most lily leaf beetle parasitoids are wasps that lay eggs inside the host and effectively kill all infected individuals.

Diaparsis jucunda (Ichneumonidae: Tersilochinae), dominates over 90% of the parasitoid infections in lily leaf beetle.

In 1996, University of Rhode Island began testing the effectiveness of biological control of lily leaf beetle using six natural parasitoids from Europe.

[18] The European parasitoid wasp Tetrastichus setifer was used in Massachusetts from 1999 to 2001; the experiment showed reduction of the beetle population.