[7] Natsir was the second Indonesian woman Olympic gold medalist, after Susi Susanti in 1992, and is later succeeded by Greysia Polii and Apriyani Rahayu in 2021.

[9][10] Among her achievements is her three back-to-back titles from the 2012–2014 All England Open;[11][12] and in 2016, she and Ahmad became the first Indonesian mixed doubles pair to win a gold medal at the Olympics.

[15] As a Tangkas player, Natsir started to rise in the women's doubles when she and her partner Natalia Christine Poluakan won some several national tournaments in 2000.

[16] She first entered the international stage at the 2001 Asian Junior Championships in Taipei Taiwan, where she and her teammates won the bronze medal in the girls' team event.

She started her journey in the IBF Grand Prix event with partner Eny Erlangga, but the duo did not gave a satisfactory results since they only finished the tournaments in the early round.

[23] In December, Natsir took part at the 2003 SEA Games in Vietnam, and won a silver in the women's doubles and a bronze in the team event.

[24] From January to October 2004, Natsir competed in the women's doubles with different partners; Poluakan, Erlangga, Rintan Apriliana, and Greysia Polii.

[25] Natsir then competed in the Pekan Olahraga Nasional, where she and her partner, Poluakan, won a gold medal for their hometown of North Sulawesi.

[27] A week later, Natsir claimed her first Grand Prix title in the Singapore Open, beating the Malaysian pair Koo Kien Keat and Wong Pei Tty with a landslide score of 15–1 and 15–4.

[34] In August, Natsir and Widianto secured the gold at the World Championships over China's up and coming Xie Zhongbo and Zhang Yawen.

[41] In April, Natsir claimed her first ever Asian Championships title by defeating Thai pair Sudket Prapakamol and Saralee Thungthongkam in the final.

[42] At the Indonesia Open in June, Natsir and Widianto unable to defend their title after lost the match to Xie Zhongbo and Zhang Yawen.

[47] As the top seeds in the IBF World Championships, Natsir and Widianto suffered a crushing defeat in the third round to Koo Kien Keat and Wong Pei Tty.

[49] At the World Cup in Yiyang, China, Natsir and Widianto convert their last year silver to gold medal by avenging the victory against Xie Zhongbo and Zhang Yawen.

[75] Natsir competed in badminton at the 2008 Summer Olympics in mixed doubles with partner Nova Widianto and earned a silver medal.

[76] She also competed in the women's doubles event with Vita Marissa but lost to Yang Wei and Zhang Jiewen of China in the first round.

[93][94] In August, Natsir and Widianto progressed to the final of the World Championships, but was defeated by Thomas Laybourn and Kamilla Rytter Juhl.

[97] Natsir then participated in her fourth Southeast Asian Games, winning a gold medal in the mixed doubles with Widianto and a silver in the women's team.

[104] Back in pairs with Widianto, they then progressed to the Singapore Open final, but was defeated by Thomas Laybourn and Kamilla Rytter Juhl.

[106] At the home soil Indonesia Open, Natsir and Widianto lost the semi-finals match to Robert Mateusiak and Nadieżda Zięba of Poland.

[107] Together with Fitriawan, she won the Malaysia Grand Prix Gold title beating Thai veterans Sudket Prapakamol and Saralee Thungthongkam in the final.

[109][110] Their debut produced positive results as they won the Macau Open, beating Hendra Aprida Gunawan and Vita Marissa in the final.

[111] A week later, Natsir and Ahmad lost to Gunawan and Marissa in the final of the Chinese Taipei Open in a close rubber games.

[112] Competing as the top seeds in the BWF World Championships, Natsir and Widianto were stopped in the quarter-finals to Zheng Bo and Ma Jin.

[113] In their last two tournaments, Natsir and Widianto were defeated by Chinese pairs Xu Chen and Yu Yang in the quarter-finals of the China Masters and to Zhang Nan and Zhao Yunlei in the second round of the Japan Open.

[6][109] In October, Natsir and Ahmad won a Grand Prix Gold title in Samarinda, Indonesia, over an independent pair Markis Kido and Lita Nurlita.

[130] Natsir and Ahmad then won the title at the Macau Open, after received a walkover by Chen Hung-ling and Cheng Wen-hsing in the final.

In the quarter-finals, they beat German pair Michael Fuchs and Birgit Michels, but they had to admit the toughness of the second seeds Xu Chen and Ma Jin in the semi-finals.

[136] Natsir participated at the 2014 Asian Games in Incheon, South Korea,[137] and won a silver medal in mixed doubles with Ahmad.

In the final, she and Ahmad ousted Lee Chun Hei and Chau Hoi Wah of Hong Kong with a score of 21–16, 21–15, and lead the head-to-head against those pair to 3–0.