LaM's holdings include some masterpieces of Pablo Picasso, Amedeo Modigliani, Joan Miró, Georges Braque, Fernand Léger, Alexander Calder and the biggest outsider art collection in France.

The museum's collection offers an overview in modern and contemporary art, including drawings, painting, sculpture, photography, prints, illustrated books and artist's books, and electronic media.

In 2002, Manuelle Gautrand was the winner of a competition for the restructuring and extension of the museum.

The building is registered in French Inventaire supplémentaire des Monuments historiques in 2000.

Manuelle Gautrand designed an extension, covering 2700 m², of which the construction ended in 2010.