She is an active member and former Provincial Secretary of the ANC Women's League in Limpopo.
Mamaregane matriculated at Mafolofolo Secondary School in Sebayeng near Polokwane in present-day Limpopo province.
[3] In 2018, Mamaregane was elected to a four-year term on the Provincial Executive Committee of the mainstream Limpopo ANC.
[5] The ANC also nominated her to serve as Chairperson of the Select Committee on Communications and Public Enterprises.
[7] In October 2022, when Mamaregane had served just over three years in the NCOP, the ANC announced that she would leave the national Parliament to be sworn into the Limpopo Provincial Legislature.