The range is extremely rugged and varied in terrain, and includes some of the highest peaks in southwestern British Columbia.

The highest is Skihist Mountain, 2,968 m (9,738 ft), crowning the Cantilever Range in the heart of the area to the west of the community of Lytton at the confluence of the Thompson and Fraser Rivers.

To the northeast of Harrison Lake, Mount Breakenridge stands 2,395 m (7,858 ft) tall and poses a significant local landslide tsunami risk to the area.

There are a number of provincial parks and recreation areas within the boundaries of the Lillooet Ranges.

"The Stein" is the largest unlogged watershed in the southern Coast Mountains and, like the rest of the Lillooet Ranges, varies from coastal-type alpine in the west to desert-canyon arid on its east.