The focal point of the district is the historic section of Limestone College campus.

The buildings on the campus are oriented towards a central lawn and fountain.

The buildings are classically inspired and include architectural styles such as Gothic Revival and Neoclassical and also a meeting house form church.

Notable buildings include the separately listed Winnie Davis Hall and Limestone Springs Hotel.

This article about a property in Cherokee County, South Carolina on the National Register of Historic Places is a stub.