She gained recognition in 2007 for portraying Jimmy Smits' character's daughter in the CBS television drama Cane.
Esco was cast in her first television guest star role in 2006, as Angie Watson in series CSI: NY.
Esco played a lingerie model who had been fired for going public about her breast cancer survival story.
[4] In 2014, Esco was cast in Ryan Murphy's pilot for HBO alongside Michelle Monaghan, Wes Bentley, Scott Speedman, and Jennifer Jason Leigh.
[6] In April 2010, Esco produced "My Friend is...", a public service announcement for the Academy Award-winning documentary The Cove alongside Oscar-winning producer Fisher Stevens joined forces with a number celebrities to bring awareness on the annual killing of dolphins in Taiji, Japan.
[9][10] She directed and starred in Free the Nipple, which was released in select theaters, video on demand and on iTunes on December 12, 2014.
The campaign featured sixteen "It" girls from around the globe that included Alexandra Richards, Annabelle Dexter Jones, Mary Charteris, Alka Balbir, Mohini Geisweiller, DJette Clara 3000, Charlotte Lebon, Hailey Gates, Nathalie Love and Rinko Kikuchi.
[13] In 2017, Esco was featured on the Audience network's Midnight Snack on Fullscreen (What's Underneath),[14] where the guests remove their clothing on camera while talking about their life.
[15] On September 9, 2009, Esco held a private screening of The Cove in New York, alongside Russell Simmons and Fisher Stevens hosting the event to bring awareness on the film.