The southern terminus of the highway is located at West 31st Street, midblock between Ninth and Tenth Avenues.

[4][5] In 1934, a number of buildings in the neighborhood were demolished to construct the 75-foot-wide (23 m) right-of-way of Dyer Avenue, an arterial street providing access to the then-under-construction Lincoln Tunnel.

It included the approach roads in Manhattan and Hudson County, New Jersey, as outlined in the Joint Study of Arterial Facilities which had been commissioned by the agency and the Triborough Bridge Authority.

The city of New York had had concerns that existing streets could not adequately handle the extra traffic from the third tube.

The New York Times stated, "In constructing the approach highway, engineers had to build a bridge under an existing bridge, provide two twin tunnels and five viaducts, depress the roadbed in part, elevate it at other places, and develop an intricate network of entrance and exit ramps at intermediate points.

[20] The highway was to be integrated into the unbuilt Mid-Manhattan Expressway, a crosstown route leading to the Queens-Midtown Tunnel, now part of Interstate 495, and be designated I-495.

The area around the Lincoln Tunnel Expressway-Dyer Avenue corridor has been rezoned for commercial and residential development as part of the Hudson Yards Redevelopment Project and the construction of the 7 Subway Extension.

The 2003 the New York City Department of City Planning issued a master plan that calls for the creation of a network of open space between Ninth Avenue and Tenth Avenue to create a park system from West 39th Street to West 34th Street.

[24][2][3] As of 2014, the PANYNJ owned about 19 acres (7.7 ha) of property in Midtown West, mostly between 31st and 41st streets and 9th and 10th avenues, much it dedicated to transportation.

[32] In September 2014, Extell Development Company purchased air rights for $30 million for a parcel between 36-37th streets.

[33][34] While approved by the PANYNJ the sale of parcels at 30th Street to the McDermont Company for a 500,000-square-foot residential tower the plans were dropped.