She played with Los Angeles Sparks teammate Candace Parker in junior leagues prior to the going to high school.

It is believed that she was the first female to reach 1,000 points, 1,000 rebounds, 500 assists, 500 blocks, and 500 steals in Illinois high school history.

[1] She spent her entire college career at Purdue University, majoring in organizational leadership and supervision (management).

Played on the 2007 USA U21 National team that won the gold at the FIBA Women's World Championship in Moscow, Russia.

On September 26, 2012, 4 days after she played her final WNBA game, Wisdom-Hylton signed with Purdue as their assistant coach for the second time.

[8] Wisdom-Hylton played for Ravenna Esperides/Glyfada in Greece for the 2009–2010 off-season for 8 games before returning to the U.S. to be an assistant coach at her alma mater, Purdue University.