Infante played college football for the University of Florida, and later served as the head coach of the Jacksonville Bulls of the USFL, and the Green Bay Packers and Indianapolis Colts of the NFL.

His offense, quarterbacked by Ken Anderson, led the Bengals to the 1981 AFC title, and a berth in Super Bowl XVI.

During the summer of 1983, he was offered and accepted the head coach position for the upstart Jacksonville Bulls; citing potentially divided loyalties, the Bengals management promptly fired him before the start of the 1983 NFL fall season.

As Infante had left the USFL months ahead of its cessation, he was able to secure work in fall 1986, unlike most of the league's other coaches.

Infante's second season, 1989, was his most successful; after a slow start, the Packers won five of their last six games, finishing 10–6, only missing the playoffs on a tie-breaker with the rival Minnesota Vikings.

A 27–7 season-ending victory over the Vikings notwithstanding, Infante was fired by the Packers' new general manager, Ron Wolf, before the beginning of the 1992 season.

After his retirement, Infante lived in Crescent Beach, Florida with his wife Stephanie, two sons and five grandchildren.