The lined pocket mouse (Chaetodipus lineatus) is a species of rodent in the family Heteromyidae.

It resembles Nelson's pocket mouse (Chaetodipus nelsonii) in size and general appearance but lacks the stiff spines that that species has among the hairs on its rump.

[3] Its coloring is also distinctive; the dorsal surface is gray faintly lined with buff giving a drab appearance, the sides are gray and the underparts are white, with a fine buff line delineating the margin between sides and belly.

[3] The lined pocket mouse is found only in the states of San Luis Potosi and Zacatecas in central Mexico where it inhabits desert plains with xerophile scrub at altitudes between 1,600 and 2,400 metres (5,200 and 7,900 ft) above sea level.

It feeds on seeds such as those of the prickly pear (Opuntia) which fall to the ground, but it does not eat the pulp of the cactus fruit.